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Lothar Sachs Publikationen von Sandra Freitag-Wolf Lutter G, Bax L, Liu Y, Hansen JH, Frank D, Freitag-Wolf S, Simionescu A, Sathananthan J, Puehler T. Transcatheter mitral valve replacement: tissue in-growth after 4 weeks. Interact Cardiovasc Thorac Surg, 32 Histological examination demonstrated progressive healing and neointimalization.

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Genome Instability Profiles Predict Disease Outcome in a Cohort of 4, Patients with Breast Cancer. Clin Cancer Res, 26 This applies especially to premenopausal patients.

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In patients receiving adjuvant therapy, the profiles improve identification of high-risk patients. Becker M, Schmied F, Kadem LF, Freitag-Wolf S, Naujokat H, Mehl C, Kern M, Harder S. Single-cell adhesion of human osteoblasts on plasma-conditioned titanium implant surfaces in vitro.

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J Mech Behav Biomed Mater, Case-only analysis of gene-gene interactions in inflammatory bowel disease. Scand J Gastroenterol, 55 Dai H, Lutter G, Frank D, Freitag-Wolf S, Topal A, Haneya A, Sathananthan J, Puehler T.

Transcatheter aortic valve resection: new mechanical devices.

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J Thorac Dis, 12 Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline. Kidney Int, The OR2S2 locus is novel for any eGFRcrea trait including interesting candidates.

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For the five gerber mark ii serial number dating significant lead variants, we found supporting effects for annual change in blood urea nitrogen or cystatin-based eGFR, but not for GATM or LARP4B. Individuals at high compared to those at low genetic risk vs adverse alleles had a 1. Thus, our identified loci for rapid kidney function decline may help prioritize therapeutic targets and identify mechanisms and individuals at risk for sustained deterioration of kidney function.

Quelle Links Bader P, Beck J, Frey A, Schlegel P, Hebarth H, Handgretinger R, Einsele H, Niemeyer C, Benda N, Faul C, Kanz L, Niethammer D, Klingebiel T Serial and quantitive analysis of mixed hematopoietic chimerism by PCR in patients with acute leukemias allows the prediction of relapse after allogenic BMT.

Seoudy H, Lambers M, Winkler V, Dudlik L, Freitag-Wolf S, Frank J, Kuhn C, Rangrez AY, Puehler T, Lutter G, Bramlage P, Frey N, Frank D. Elevated high-sensitivity troponin T levels at 1-year follow-up are associated with increased long-term mortality after TAVR.

Clin Res Cardiol, High Levels of Chromosomal Copy Number Alterations and TP53 Mutations Correlate with Poor Outcome in Younger Breast Cancer Patients.

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Am J Pathol, To understand the genetic basis of the disparate clinical courses, tumors were collected from 34 younger women, 17 with good and 17 with poor outcomes, as determined by disease-specific survival during a follow-up period of 17 years. The clinicopathologic parameters of the tumors were complemented with DNA image cytometry profiles, enumeration of copy numbers of eight breast cancer genes by multicolor fluorescence in situ hybridization, and targeted sequence analysis of cancer genes.

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Both groups included diploid and aneuploid tumors. The degree of intratumor heterogeneity was significantly higher in aneuploid versus diploid cases, and so were gains of the oncogenes MYC and ZNF Significantly more copy number alterations were observed in the group with poor outcome.

Almost all tumors in the group with long survival were classified as luminal A, whereas triple-negative tumors predominantly occurred in the short survival group.

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Mutations in PIK3CA were more common in the group with good outcome, whereas TP53 mutations were more frequent in patients with poor outcomes. This study shows that TP53 mutations and the extent of genomic imbalances are associated with poor outcome in younger breast cancer patients and thus emphasize the central gerber mark ii serial number dating of genomic instability vis-a-vis tumor aggressiveness.

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Genetic Imbalance Is Associated With Functional Outcome After Ischemic Stroke. Stroke, 50 Subgroup analyses were confined to patients with imbalance affecting ohnologs-a class of dose-sensitive genes, or to those with imbalance not affecting ohnologs.


The association of imbalance with outcome was analyzed by logistic regression analysis, adjusted for age, sex, stroke subtype, stroke severity, and ancestry. Results- The study sample comprised CADISP patients age The association was independent of age, sex, stroke severity on admission, stroke subtype, and ancestry.

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Conclusions- Increased genetic imbalance was associated with poorer functional outcome after IS in both study populations. Subgroup analysis revealed that this association was driven by presence of ohnologs in the respective copy number variations, suggesting a causal role of the deleterious effects of genetic imbalance. Periprocedural Changes of NT-proBNP Are Associated With Survival After Transcatheter Aortic Valve Implantation.

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J Am Heart Assoc, 8e Median follow-up was Conclusions A ratio based on periprocedural changes of NT-proBNP is a simple tool for better risk stratification and is associated with survival in patients after transcatheter aortic valve implantation.

Puehler T, Freitag-Wolf S, Friedrich C, Salem M, Renner J, Cremer J, Haneya A. Outcomes of Patients after Implantation of the Pericardial All-Biological Valve No-React Aortic Conduit BioIntegral for Root Replacement in Complex Surgical Procedures.